The gene encoding SERPINE1 mRNA binding protein 1 (SERBP1) is localized on human chromosome 1p31.
Synonyms: Anti-PAI-RBP1; Anti-PAI1 RNA-binding protein 1; Anti-Plasminogen activator inhibitor 1 RNA-binding protein; Anti-SERPINE1 mRNA-binding protein 1
Storage: -20C
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Biochem Physiol Actions: SERPINE1 mRNA binding protein 1 (SERBP1) may regulate the stability of the mRNA encoding plasminogen activator inhibitor 1 (PAI-1). It has been shown to be overexpressed in breast and ovarian cancers. SERBP1 binds to the carboxy terminal end of chromo-helicase-DNA-binding domain protein-3 (CHD-3) and might be associated with chromatin architecture. It also facilitates the non-nuclear functions of progesterone by interacting with progesterone receptor membrane component-1 (PGRMC1).
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