SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1) is a cytoplasmic adaptor protein belonging to the SLY family. It is abundantly expressed in the hematopoietic compartment. Its expression to a lesser extent have also been found in heart, brain, placenta, and lung. Generally, they are characterized by the presence of protein-protein interaction domains. It consists of a sterile motif (SAM) domain that is capable of self-association and can also associate with each other. The chimeric fusion of this domain with the ßPDGF receptor, AML1, c-Abl, and JAK2 results in the oncogenic transformation of the SAM domain. The SH3 domains mediate protein-protein interactions in several signal transduction pathways.
Synonyms: Anti-Hematopoietic adaptor containing SH3 and SAM domains 1; Anti-SAM domain, SH3 domain and nuclear localization signals protein 1; Anti-SAM domain-containing protein SAMSN-1; Anti-SH3-SAM adaptor protein
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Biochem Physiol Actions: SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1) protein may be involved in the formation of blood vessel during normal brain development. It may function as an adaptor or scaffold protein. It has been found to be overexpressed in glioma cells and is associated with a poor survival in glioblastoma multiforme. SAMSN1 may be involved in B cell activation and differentiation. SAMSN1 has been suggested to be a tumor suppressor in lung cancer. It has also been reported that SAMSN1 may act as a biomarker for the phenotype of human hepatocellular carcinoma.
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