Mucin 5B (MUC5B) gene is mapped to human chromosome 11p15.5. It codes for a 3570 amino acid peptide characterized with a Cys-subdomains of 108 amino acids.
Synonyms: Anti-Cervical mucin; Anti-High molecular weight salivary mucin MG1; Anti-MUC-5B; Anti-Mucin-5 subtype B, tracheobronchial; Anti-Mucin-5B precursor; Anti-Sublingual gland mucin
Storage: -20C
Application: Anti-MUC5B antibody produced in rabbit has been used in immunofluorescence
Biochem Physiol Actions: Mucin 5B (MUC5B) plays a vital role in maintaining immune homeostasis in the lungs by facilitating mucociliary clearance (MCC). Mucins are the key components that imparts gel-like properties to the mucus.(7) Mutation in the gene leads to the development of idiopathic pulmonary fibrosis. Upregulated expression of MUC5B in the ear causes middle ear effusions.
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