LRSAM1 (leucine-rich repeat and sterile a motif-containing protein 1) is a chromosome 9q33.3 located gene consisting of a leucine-rich repeat (LRR), an ezrin-radixin-moezin (ERM) domain, a coiled-coil (CC) region, a SAM (sterile a motif) domain and a carboxyl-terminal C3HC4-type RING (really interesting new gene) finger domain.
Synonyms: Anti-E3 ubiquitin-protein ligase LRSAM1; Anti-Leucine-rich repeat and sterile alpha motif-containing protein 1; Anti-Tsg101-associated ligase; Anti-hTAL
Storage: -20C
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Biochem Physiol Actions: LRSAM1 (leucine-rich repeat and sterile a motif-containing protein 1) is an E3 type ubiquitin ligase involved in membrane vesicle fusion during viral maturation and neuronal adhesion during muscle control activity. It binds to Tsg101 (tumor susceptibility gene 101) to ubiquitinate it, which further inactivates Tsg101-mediated sorting of endocytic (epidermal growth factor receptors) and exocytic (viral proteins) cargoes. It also protects cytoplasm from invasive pathogens by participating in ubiquitination associated with intracellular bacteria. Mutations in LRSAM1 cause Charcot-Marie-Tooth (CMT) disease.
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