Frizzled class receptor 6 (FZD6) is a 706 amino-acid, membrane-bound receptor. It possesses seven transmembrane domains, an N-terminal region with a cysteine-rich domain and two N-linked glycosylation sites. The gene encoding FZD6 is localized on chromosome 8q22.3.
Synonyms: Anti-Frizzled-6 precursor; Anti-Fz-6; Anti-hFz6
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Frizzled class receptor 6 (FZD6) acts a molecular switch between various Wnt pathways. FZD6 is needed for the genes of the non-canonical pathway to be expressed and the growth of the nail plate in humans. Mutations in the gene encoding it have been linked to nail dysplasia.
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