CD34 (cluster of differentiation 34) molecule, a cell surface antigen, is expressed in hematopoietic stem cells and vascular endothelium. This gene is 26 kb in length and contain 8 exons. CD34 is a 115 kDa type I transmembrane glycoprotein with a protein backbone of approximately 40 kDa. It is also expressed on all vascular endothelial cells of adults and embryos. CD34 is located on human chromosome 1q32.
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CD34 (cluster of differentiation 34) plays an important role in modulation of cell/cell or cell/matrix adhesion. It may play a key role in adhesion and signal transduction on hematopoietic progenitor/stem cells. CD34 may also participate in the maintenance or proliferation of the hematopoietic progenitor/stem cells.
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