ARID5B (AT rich interactive domain 5B) belongs to the family of DNA-binding proteins called AT-rich interaction domain (ARID). This gene is localized to human chromosome 10q21.2. This protein contains three ARID domains, which includes six a-helices in the central region, called H1 to H6. The other two domains are called L1 and L2, which are DNA-binding loops.
Synonyms: Anti-ARID domain- containing protein 5B; Anti-AT-rich interactive domain-containing protein 5B; Anti-MRF-2; Anti-Modulator recognition factor 2; Anti-Mrf1-like
Storage: -20C
Application: Anti-ARID5B antibody produced in rabbit has been used in chromatin immunoprecipitation (ChIP) and western blotting.
Biochem Physiol Actions: ARID5B (AT rich interactive domain 5B) controls adipogenesis and liver development, by regulating the transcription of involved genes. It interacts with DNA by binding with PHD finger protein 2, to form a histone H3K9me2 demethylase complex. This gene influences the development and differentiation of hematopoietic cells, and variants in this gene are linked with childhood acute lymphoblastic leukemia (ALL). Studies in Spanish population show that intron 3 of this gene is a hot spot for susceptibility to acute lymphoblastic leukemia. It also strongly influences cell growth and differentiation, and the development of embryo.
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