ANXA4 (annexin A4) gene encodes a protein that is a member of the annexin family of calcium-dependent phospholipid binding proteins. These proteins contain divergent NH2-terminal 'head' domain that confers specific properties to the individual annexin and a conserved 34kDa COOH-terminal protein core that binds to calcium and membrane. Annexin 4 was first identified in homogenates of human placenta. It is expressed in several tissues such as secretory epithelia in the lung, stomach, intestine, and kidney. It is associated with polarized epithelial cells.
Synonyms: Anti-35-beta Calcimedin antibody produced in rabbit; Anti-Annexin A4 antibody produced in rabbit; Anti-Annexin IV antibody produced in rabbit; Anti-Carbohydrate-binding protein P33/P41 antibody produced in rabbit; Anti-Chromobindin-4 antibody produced in rabbit; Anti-Endonexin I antibody produced in rabbit; Anti-Lipocortin IV antibody produced in rabbit; Anti-P32.5 antibody produced in rabbit; Anti-P33/41 antibody produced in rabbit; Anti-PAP-II antibody produced in rabbit; Anti-PP4-X antibody produced in rabbit; Anti-Placental anticoagulant protein II antibody produced in rabbit; Anti-Protein II antibody produced in rabbit
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: ANXA4 (annexin A4) may function in the regulation of chloride ions across the epithelial membrane. It has been suggested to play a role in normal pronephrogenesis in Xenopus laevis. It has been identifies as a candidate biomarker for cisplatin resistance in malignant mesothelioma.
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