Synonyms: 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indole malate; PNU 180638
Molecular Formula: C17H25N3O2S · C4H6O5
Molecular Weight: 469.55
Linear Structural Formula: C17H25N3O2S · C4H6O5
Purity: >=98% (HPLC)
Storage: -20C
Application: Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.
Biochem Physiol Actions: Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.