Synonyms: Delta13-Dehydrochaparrinone; (1beta,11beta,12alpha)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione; 13,21-Didehydrochaparrinone
Molecular Formula: C20H24O7
Molecular Weight: 376.4
Linear Structural Formula: C20H24O7
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Ailanthone, natural compound isolated from Ailanthus altissima (Simaroubaceae), is a potent inhibitor of androgen receptor (AR) that blocks activities of full-length AR and AR splice variants. It overcomes MDV3100 (Enzalutamide)-resistance in castration-resistant prostate cancer cell lines. Ailanthone disrupts the interaction between AR and the chaperones HSP90, HSP70, and HSP40, which leads to AR ubiquitination and degradation.