Synonyms: Ac-SDKP-OH trifluoroacetate; Ac-Ser-Asp-Lys-Pro-OH trifluoroacetate; AcSDKP trifluoroacetate; Goralatide trifluoroacetate; N-acetyl-L-seryl-L-a-aspartyl-L-lysyl-L-proline trifluoroacetate; N-acetyl-Ser-Asp-Lys-Pro-OH trifluoroacetate; Thymosin ß4 (1-4) trifluoroacetate; Tß4 (1-4) trifluoroacetate
Molecular Formula: C20H33N5O9 · xC2HF3O2
Linear Structural Formula: C20H33N5O9 · xC2HF3O2
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: Originally characterized as a "spleen colony-forming units (CFU-S) inhibitor" for its activity against hematopoietic pluripotent stem cell proliferation, Ac-SDKP (Goralatide) is an immunomodulatory and pro-angiogenic tetrapeptide derived from the N-terminal end of thymosin beta4 (Tbeta4 aa 1-4) via sequential enzymatic actions of meprin-alpha and prolyl-oligopeptidase (POP), while angiotensin converting enzyme (ACE) mediates Ac-SDKP degradation. In animal heart, kidney and brain injury studies, Ac-SDKP ameliorates end-organ damage by promoting angiogenesis, as well as by reducing inflammation and fibrosis.