Synonyms: 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide; 2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide; AZD 2098; AZD2098
Molecular Formula: C11H9Cl2N3O3S
Molecular Weight: 334.18
Linear Structural Formula: C11H9Cl2N3O3S
MDL Number: MFCD31382158
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 muM) with little or no activity toward a panel of >=120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 mumol/kg p.o.; 1 h before and every 12 h after antigen challenge).