Synonyms: 3-Benzyl-5-((2-nitrophenoxy)methyl)-dihydrofuran-2(3H)-one
Molecular Formula: C18H17NO5
Molecular Weight: 327.33
Linear Structural Formula: C18H17NO5
Purity: >=98% (HPLC)
Storage: 2-8C
Application: 3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.
Biochem Physiol Actions: An orally bioavailable, brain-permeant suppressor of mTOR-mediated autophagy; reduces Aß levels and prevents cognitive deficits in AßPP/PS1 mouse model.3-benzyl-5-[(2-nitrophenoxy) methyl]-dihydrofuran-2 (3H)-one (3BDO) blocks rise in LC3-II stimulated by uric acid (UA). It protects the capability of Rheb1-deficient macrophages to perform phagocytosis. 3BDO also prevents the inhibitory effects of EX-527 on eukaryotic translation initiation factor-binding protein 1(4E-BP1) phosphorylation.