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MilliporeSigma

2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid >=95%

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Synonyms: Semi-flexible linker for PROTAC(R) development

Molecular Formula: C18H25NO4

Molecular Weight: 319.4

Linear Structural Formula: C18H25NO4

MDL Number: MFCD32198954

Purity: >=95%

Storage: 2-8C

Application: 2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationCrosslinkers for BioconjugationPortal: Building PROTAC(R) Degraders for Targeted Protein Degradation

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Product Detail
Thomas No.
CHM02V365
Mfr. No.
917915-100MG
CAS #
1338795-60-0
Description
917915-100MG, 2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid >=95%
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