Glutathione disulfide (GSSG) is the oxidised dimeric form of glutathione (GSH), which is a naturally occuring tripeptide that takes part in the bodies detoxification mechanisms and protects against oxidative damage. Glutathione Oxidized acts as hydrogen acceptor in enzymic determination of NADP and NADPH.
In vivo, Glutathione disulfide (GSSG) is reduced back to glutathione (GSH) via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress.
Key Applications: Determination of level of oxidative stress in cells
Application Areas: Cell Biology & Analysis
Product Type: Biochemicals
Biochemical Category: Proteins and Peptides
Melting Point: 178°C (dec.)(Lit.)
Optical Rotation: (c=1, water) - 85° to -110°
Presentation: White Crystalline Powder
Format: Crystalline Powder
pH: Acidic to Litmus Paper (3.3% aq soln)
Detection Method: FTIR
NOTES:
Amino Acid Sequence:Glu-Cys-Gly, Glu-Cys-Gly [Disulfide bridge: 2a-2b]
Solubility: Soluble in water (3.3%): Clear, Colorless Solution.
Storage & Handling: Store at +4°C.