Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction and intracellular signal transduction (cGMP). When guanine is attached by its N9 nitrogen to the C1 carbon of adeoxyribose ring it is known as deoxyguanosine.
Guanosine is required for an RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein. The antiviral drug aciclovir, often used in herpes treatment, is structurally similar to guanosine.
Purity: 97 - 103%
Key Applications: RNA splicing
Product Type: Biochemicals
Biochemical Category: Nucleotides & Nucleic Acids
Chemical Class: Nucleotides & Nucleic Acids
Melting Point: 250°C (Lit.)
UV/Visible Absorbance: λ max (water) 251 ± 3 nm. OD250/OD260 <1.3. OD280/OD260 <0.69. OD290/OD260 <0.26
Presentation: Off white powder
Solubility: Clear to very slightly hazy colorless to faint yellow solution at 50mg/ml in Formic acid : water (1:1)
Storage & Handling: Room Temperature