Adenosine is a nucleotide resulting from the union of one molecule of sugar -- d-ribose -- with a base -- l-adenine.
- Active in cardiovascular disorders
- Indicated in cases of angina pectoris
- Increases coronary output
- Vasodilator action
- Induced apoptosis in human leukemia HL-60 cells
- Has anti-arrhythmic properties
Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).
Purity: ≥98%
Key Applications: Treatment of cardiovascular disorders and agranulocytosis
Product Type: Biochemicals
Gene Id: human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066) rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370)
Density 2.09 g/cm3 (Lit.)
Boiling Point: 676.27°C at 760 mmHg (lit.)
Melting Point: 228 - 236°C
Extinction Coefficient (E1%): 15.4 (259 nm in 0.01 M PO4, pH 7)
Optical Rotation: α20/D -70 °, c = 2 in 5% NaOH (lit.)
Refractive Index: n20D 1.91 (Lit.)
UV/Visible Absorbance: λmax (1N HCl)-255 - 260 nm OD250/OD260 - 0.80 - 0.90 OD280/OD260 - 0.17 - 0.24
Presentation: White Powder
Format: Free Base, Powder
Detection Method: FTIR
Solubility: Fairly soluble in cold water, soluble in room temperature water, freely soluble in hot water; soluble in 1 N hydrochloric acid (50 mg/mL - clear and colorless); insoluble in alcohol.
Storage & Handling: Store at -20°C.