SIGMA (±)-α-Lipoic acid, BioReagent, cell culture tested, =99%

Synonyms: (±)-1,2-Dithiolane-3-pentanoic acid; 6,8-Dithiooctanoic acid; DL-α-Lipoic acid; DL-6,8-Thioctic acid; Lip(S₂)

Formula: C₈H₁₄O₂S₂

Formula Weight: 206.33

CAS No.: 1077-28-7

Purity: ≥99%

Biochem/physiol Actions: Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.

Other Notes: Oxidized form