Synonym(s): 4,4,5,5-Tetramethyl-2-(1H-pyrazol-2-yl)-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(1H-pyrazol-4-yl)-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(pyrazol-4-yl)-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; Pyrazol-4-ylboronic acid pinacol ester
Formula: (CH3)4C2O2BC3N2H3
Formula Weight: 194.04
CAS No.: 269410-08-4
Purity: 97%
Application: Reagent used for
• Suzuki-Miyaura cross-couplings
• Ruthenium-catalyzed asymmetric hydrogenation
Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
• VEGF
• Aurora3,
• Rho (ROCK)
• Janus Kinase 2 (JAK)
• c-MET
• ALK
• S-nitrosoglutathione reductase
• CDC7
• Acetyl-CoA carboxylase
• Prosurvival Bcl-2 protein
• Viral RNA-Dependent RNA polymerase
• Long Chain Fatty Acid Elongase 6
• PI3
• AKT
• Chk1
• Protein Kinase B
Legal Information: Product of Boron Molecular
Packaging: 1, 5, 25 g in glass bottle
Melting Point: 142-146°C(lit.)
Empirical Formula (Hill Notation): C6H7FN2