Synonyms: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; AEBSF
Formula: C8H10FNO2S · HCl
Formula Weight: 239.69
CAS No.: 30827-99-7
Purity: ≥98.0% (HPLC)
Storage Temperature: 2-8°C
Application: Recommended concentrations for use are 0.1-1 mM.
Biochem/physiol Actions: Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25-ámM.
Other Notes: Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic1,2; Unaffected by albumin3
Legal Information: Pefabloc is a registered trademark of Pentapharm
Assay: ≥98.0% (HPLC)
Grade: analytical standard
MP: ~183°C
Storage Temp.: 2-8°C