Synonyms: N-(4-(7-Chloro-2H-benzo[b][1,4]oxazin-3-yl)phenyl)acetamide; N-[4-(7-Chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide; QX 77; QX-77
Molecular Formula: C16H13ClN2O2
Molecular Weight: 300.74
Linear Structural Formula: C16H13ClN2O2
MDL Number: MFCD31657441
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: QX77 is a chaperone-mediated autophagy (CMA) activator derived from the atypical retinoid AR7 that activates CMA by antagonizing retinoic acid receptor-alpha (RARalpha) signaling. QX77 rescues defective trafficking & lysosomal localization of the CMA receptor LAMP2A in cystinotic Ctns-/- MEFs and CTNS-KO human proximal tubule cells (PTCs) by restoring Rab11 expression and Rab11-positive vesicles trafficking to the level seen in wild-type cells (20 muM, 48 hrs). CMA activation by QX77 treatment (20 muM, 5 days) also significantly reduces toxic alpha-synuclein (alpha-syn) accumulation in PD patients iPSCs-derived astrocytes with LRRK2 G2019S mutation.