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Bio Basic Inc.

Tumor Necrosis Factor-a Variant; Human TNF-a Variant

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TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human: The clinical use of the potent antitumor activity of TNF-αhas been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage.

Designing clinically applicable TNF-αmutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-R55 but not to the murine TNF-R75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors.

Based on these results, many TNF-αmutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo., UnitProt ID: P01375

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Thomas No.
C861N53
Mfr. No.
RC214-12V.SIZE.10ug
Description
Tumor Necrosis Factor-a Variant; Human TNF-a Variant, 10ug

list price/quantitytotal
$0.00
Thomas No.
C861N54
Mfr. No.
RC214-12V.SIZE.50ug
Description
Tumor Necrosis Factor-a Variant; Human TNF-a Variant, 50ug

list price/quantitytotal
$0.00
Thomas No.
C861N55
Mfr. No.
RC214-12V.SIZE.1mg
Description
Tumor Necrosis Factor-a Variant; Human TNF-a Variant, 1mg

list price/quantitytotal
$0.00
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