SDF-1 beta, rHuSDF-1 beta, CXCL12, human: CXCL12 also known as SDF-1 is belonging to the CXC chemokine family. It is encoded by the CXCL12 gene.
In recently study, Human CXCL12 is expressed as six isoforms that differ only in the C-terminal tail.
And all SDF-1 isoforms undergo proteolytic processing of the first two N-terminal amino acids.
In all SDF-1 isoforms, SDF-1β is the canonical sequence.
It has the complete amino acids in the C-terminal tail.
On the cell surface, the receptor for this chemokine is CXCR4 and syndecan4.
CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils.
CXCL12 is a very important factor in carcinogenesis and the neovascularization linked to tumor progression., UnitProt ID: P48061