Bleomycin Sulfate is an atineoplastic antibiotic.
A mixture of cytotonic glycopeptide antibiotics which reacts with DNA and causes strand scission; they have also been shown to have a type of oxygen transferase activity. Bleomycin A2 is the main component of the bleomycin employed clinically. Bleomycins differ from one another in the terminal amine and show varying biological activity.
Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
Concentration: 10 - 100 µg/mL
Key Applications: It is used in research as antibiotics, antifungal
Application Areas: Chemicals, Life Sciences
Product Type: Biochemicals
Biochemical Category: Pharmaceuticals
Solubility: Very soluble in water, methanol; slightly soluble in ethanol. Practically insoluble in acetone, ethyl acetate, butyl acetate, ether.
Storage & Handling: Store at 2-8°C, Store Desiccated & protect from light.