Antigen: human Apaf-1 amino acids 12-28; the sequence of the peptide is identical between human and mouse
Host: rabbit
Cross Reactivity: (+) human and mouse Apaf-1
Application(s): WB
Apaf-1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. It can also associate with caspase-4 and -8.