Synonym: ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid
CAS Number: 302-79-4
Empirical Formula (Hill Notation): C20H28O2
Molecular Weight: 300.44
Packaging: 1, 5 g in ampule
Packaging: 50, 100, 500 mg in ampule
Biochem/physiol Actions:
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.