Synonyms: 8-MOP; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; Ammoidin; Methoxsalen; Xanthotoxin
Formula: C12H8O4
Formula Weight: 216.19
CAS No.: 298-81-7
Biochem/physiol Actions: 8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].
Caution: Protect from light.
Packaging: 1, 5 g in glass bottle
Color: white to yellow
Form: powder
Gene Information: rat ... Maoa
MP: 148-150°C(lit.)
Solubility: acetic acid: soluble