Etoposide, synthetic, =98%, powder

Synonym: 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside), VP-16-213

CAS Number: 33419-42-0

Empirical Formula (Hill Notation): C₂₉H₃₂O₁₃

Molecular Weight: 588.56

EC Number: 251-509-1

MDL Number: MFCD00869325

PubChem Substance ID: 24278178

Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions
Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.