Rapamycin

…Inhibition by rapamycin results in cell cycle arrest in G1. Rapamycin also has been shown to have a role in life span extension in mice.  Soluble in DMSO or Ethanol PubChem Chemical ID: 5284616 Features Synomyms: Rapamune; Sirolimus; (-)-Rapamycin; Rapamycin from Streptomyces…

…Induces autophagy in yeast and mammalian cell lines. Rapamycin binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.

Rapamycin (Sirolimus) is a triene macrolide antibiotic, which demonstrate anti-fungal, anti-flammantory, anti-tumor and immunosuppressive properties. Purity > 98.8% High Purity Grade White crystalline powder. Hygroscopic. Protect from light and moisture. Soluble in DMSO and…

Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the mammalian target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an alternative to calcineurin…

An immunosuppressant used to prevent transplant rejection; potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM); specifically interacts with FKBP12 to form a complex which inhibits mTORC1.

A nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration; secreted from cells by P-glycoprotein; poorly activates mTOR but, like rapamycin, inhibits the proteasome.

… Biochem/physiol Actions A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.

Consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker, which are released upon hydrolysis of the prodrug linker in vivo; inhibits the growth of tumors in mice better than rapamycin alone.

Synonym(s): Sirolimus, AY-22989 Formula: C51H79NO13 Formula weight: 914.17 Purity: 99+% CAS Number: 53123-88-9 Harmonized Tariff Code:  2934.99

The RICTOR antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human RICTOR. This antibody recognizes human,mouse antigen. The RICTOR antibody has been validated for the following applications: ELISA, WB analysis.

Formula: C₅₁H₇₉NO₁₃ Formula Weight: 914.17 CAS No.: 53123-88-9 Storage Temperature: −20°C Legal Information: VETRANAL is a trademark of Sigma-Aldrich Co. LLC

Species : Human Assay Principle : Quantitative Target Name : FK506 binding protein 12-rapamycin associated protein Sensitivity : 10 pg/ml Detection Range : 25pg/ml-800 pg/ml

…Number: 200-664-3 Biochem/physiol Actions Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide…

Synonym(s): FRAP; FRAP1; FRAP2; RAFT1; Rapamycin target protein Storage: −20°C

Synonym(s): FRAP; FRAP1; FRAP2; RAFT1; Rapamycin target protein Storage: −20°C

This affinity purified antibody has been tested for use in immunohistochemistry, ELISA and western blotting. Western blotting shows reactivity specific for phospho mTOR detecting a band at approximately 250 kDa.  Reactivity in other immunoassays is unknown.

This affinity purified antibody is suitable for use in ELISA and western blotting. ELISA data demonstrate reactivity against both phosphorylated and non-phosphorylated mTOR at S2448 and western blotting shows a band at approximately 250 kDa.  Reactivity in other immunoassays is unknown.

Synonyms: KIAA1303; RAPTOR; RPTOR; Regulatory-associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold protein Storage: -20C

HOST SPECIES: Rabbit CLONALITY: Polyclonal TESTED APPLICATIONS: E, WB, IHC-P, IF APPLICATIONS: GbL antibody can be used for the detection of GbL by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start…

A hydroxyethyl ether rapamycin derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM; orally available with superior pharmacokinetics and pharmacodynamics over rapamycin.

Anti-GBL Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 36 kDa in Western Blots of specific cell lysates and tissues.

The human MAPKAP1-6*his fusion protein from Proteintech is 1 - 324 aa of human MAPKAP1 expressed in E. coli with the expression vector PET28a. This protein has been detected in SDS-page gel. The protein is lyophilized powder.

HOST SPECIES: Rabbit CLONALITY: Polyclonal TESTED APPLICATIONS: E, WB, IHC-P APPLICATIONS: MAPKAP1 antibody can be used for detection of MAPKAP1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. Antibody validated: Western…

HOST SPECIES: Rabbit CLONALITY: Polyclonal TESTED APPLICATIONS: E, WB, IHC-P, IF APPLICATIONS: MAPKAP1 antibody can be used for detection of MAPKAP1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence…

The human RICTOR-6*His fusion protein from Proteintech is 1 - 183 aa of human RICTOR expressed in E. coli with the expression vector PET30a. This protein has been detected in SDS-page gel. The protein is lyophilized powder.

Synonym(s): 42-[3-Hydroxy-2-methylpropanoate; CCI-779; Rapamycin Empirical Formula: C₅₆H₈₇NO₁₆ Linear Formula: C₅₆H₈₇NO₁₆ Formula Weight: 1030.29 MDL Number: MFCD00934421 Purity: ≥98% (HPLC) Storage: room temp

…target of rapamycin complex 1 (mTORC1) inhibitor to study its effect on MCF7 and MDA-MB-231 cell lines. Biochem Physiol Actions: Everolimus, the 40-O-(2-hydroxyethyl) derivative of rapamycin (sirolimus), is a potent and selective inhibitor of mechanistic target of rapamycin (mTOR). Everolimus…