Signal Transduction

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Signal Transduction

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  • 4-Phorbol 12-Myristate 13-Acetate (Pma)

    Enzo Life Sciences

    99%, MW=616.8 [63597-44-4] Storage: -20°C Negative control for phorbol 12-myristate 13-acetate (PMA).

  • Anti-Histone Deacetylase 1, 100 ug

    Enzo Life Sciences

    Rabbit polyclonal antibody Immunogen: C-terminal human HDAC1 (467-482) Supplied as epitope affinity purified IgG with 1 mg/ml BSA and 0.05% sodium azide in PBS. Recognizes human HDAC1 (approximately 62 kDa). Applications: Western Blotting 1/2000, Immunoprecipitation.

  • Caspase-7, 5000 U

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=20 + 12 kDa Storage: -80°C Caspase -7 1,2 is an effector caspase 3,4 in apoptosis with similar substrate preferences to caspase-3. Like caspase-3, it can cleave PARP-1 5-7 . It displays an affinity for ADP-ribose polymers and automodification of PARP-1…

  • MMP-3 Colorimetric Assay Kit, For Drug Discovery

    Enzo Life Sciences

    A QuantiZyme™ Assay System. The MMP-3 Colorimetric Assay Kit for Drug Discovery is a complete assay system designed to screen inhibitors of matrix metalloproteinase-3 (MMP-3, Stromelysin-1) using a thiopeptolide as a colorimetric substrate 1,2 . The MMP cleavage site peptide bond is replaced…

  • MIT-E-PSI Mitochondrial Permeability Kit

    Enzo Life Sciences

    The Mit-E-ψ ™ Kit detects the change in mitochondrial permeability which is an early indication of the initiation of cellular apoptosis. The resulting change in membrane potential, (Δ ψ ) can be detected by a unique fluorescent cationic dye,…

  • RII Phosphopeptide, Calcineurin Substrate, 500 ug

    Enzo Life Sciences

    Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-pSer-Val-Ala-Ala-Glu >97%, MW=2192.0, Storage: -20°C Sequence is from cAMP-dependent protein kinase (PKA) regulatory subunit type II (RII), but with a phosphoserine at Ser-95. This peptide can be used directly as a calcineurin…

  • Wortmannin

    Enzo Life Sciences

    98%, MW=428.4 [19545-26-7] Storage: -20°C Wortmannin, a fungal metabolite, is a potent and selective inhibitor of phosphatidylinositol 3-kinase 1 . It is active in purified preparations and cytosolic fractions (IC50=5 nM) and is highly cell permeable. It inhibits fMLP…

  • Ly 294002

    Enzo Life Sciences

    2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99%, MW=307.4 [154447-36-6] Storage: -20°C LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase). In in vitro assays using purified PI 3-kinase, LY 294002 displays an IC50

  • Caspase-9, Caspase-9 Full Length

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=20 + 12 kDa Storage: -80°C Caspase-9 is the initiator caspase of the mitochondrial/Apaf-1 apoptosis induction pathway 3-6 . This active caspase-9 (ICE-LAP-6; Mch6) is made from a human cDNA, expressed in E. coli. cDNA encodes residues identical to Ile-131 to…

  • Ag-825

    Enzo Life Sciences

    98%, MW=397.5, Storage: RT 5-[(Benzthiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide. A selective HER1-2 (HER2-Neu) 1 tyrosine kinase inhibitor 2 . 1. A. Levitzki et al., "Science" 1995, 267: 1782 2. H. Daub et al., "Nature" 1996, 379: 559

  • HBDDE

    Enzo Life Sciences

    97%, MW=338.4 Storage: -20°C 2,2',3,3'4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether. Inhibits PKCα ; (IC50=43 µM) and PKCγ ; (IC50=50 µM) without inhibiting the δ , β I and β II isotypes 1 . 1. Y. Kashiwada et al., "J.…

  • Cyclosporin A

    Enzo Life Sciences

    >98%, MW=1202.6 [59865-13-3] Storage: -20°C Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex…

  • Rapamycin

    Enzo Life Sciences

    98%, MW=914.2 [53123-88-9] Storage: -20°C Rapamycin is one member of a family of macrolide immunosuppressants which bind to and inhibit the FK506 binding protein (FKBP) proline rotamase 1 . Rapamycin is bound simultaneously by FKBP12 and FRAP (FKBP12-Rapamycin-Associated-Protein) 2 .…

  • Protein Tyrosine Phosphate, 50 ug

    Enzo Life Sciences

    >95% by SDS-PAGE, MW=37.4 kDa Storage: -70°C Human protein tyrosine phosphatase (residues 1-322), expressed in E. coli. PTP1B is the ubiquitous, prototypical nontransmembrane PTP originally identified in human placenta 1,2 . Useful for the study of tyrosine phosphatase kinetics,…

  • Bapta, Free Acid

    Enzo Life Sciences

    97%, MW=476.4 [85233-19-8] Storage: -20°C 1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid. BAPTA is a Ca 2+ chelator with 105-fold greater affinity for Ca 2+ than for Mg 2+ 1,2 . BAPTA, free acid is not cell permeable and therefore is useful as an extracellular calcium…

  • IR5,9,10, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-pTyr-Glu-Thr-Asp-pTyr-pTyr-Arg-Lys >97%, MW=1863.0, Storage: -20°C Substrate for protein tyrosine phosphatases 1,2 . 1. C. Ramachandran et al., "Biochemistry" 1992, 31: 4232 2. M.J. King and G.J. Sale, "FEBS Lett." 1988, 237: 137

  • PD-98059, 5 mg

    Enzo Life Sciences

    >95%, MW=267.3 [167869-21-8] Storage: -20°C PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase 1,2 . PD-98059 is cell permeable. In PC12…

  • MMP-12 Fluorescent Assay Kit, For Drug Discovery

    Enzo Life Sciences

    A QuantiZyme™ Assay System. The MMP-12 Fluorescent Assay Kit for Drug Discovery is a complete assay system designed to measure protease activity of matrix metalloproteinase-12 (MMP-12, metalloelastase, macrophage elastase) using a quenched fluorescent peptide: OmniMMP™ fluorescent…

  • U-0126

    Enzo Life Sciences

    98%, MW=380.5, Storage: RT A novel, potent and selective MEK inhibitor, MEK1 IC50=72 nM, MEK2 IC50=58 nM 1 . 1. M.F. Favata et al., "J. Biol. Chem." 1998, 273: 18623

  • Phorbol 12,13-Dibutyrate

    Enzo Life Sciences

    99%, MW=504.6 [37558-16-0] Storage: -20°C PKC activator 1 (10-100 ng/ml). 1. M. Castagna et al., "J. Biol. Chem." 1982, 257: 7847

  • Caspase-5, 5000 U

    Enzo Life Sciences

    >90% by SDS-PAGE, MW=18 + 11 kDa Storage: -80°C Caspase-8 is an initiator caspase activated in the death-inducing signaling complexes (DISCs) of the TNF receptor superfamily (e.g. TRAIL, FasL, TNFα receptors) 1,2,7,9 . Highly active caspase-8 (FLICE; Mch5; MACH) from human…

  • Phorbol 12-Myristate 13-Acetate (PMA), 1 mg

    Enzo Life Sciences

    (12-tetradecanoyl phorbol 13-acetate, TPA) 99%, MW=616.8 [16561-29-8] Storage: -20°C PKC activator 1,2 (10-100 ng/ml). 1. M. Castagna et al., "J. Biol. Chem." 1982, 257: 7847   2. W.J. Ryves et al., "FEBS Lett." 1991, 288: 5

  • MMP-3 Catalytic Domain, 10 ug

    Enzo Life Sciences

    (Matrix Metalloproteinase-3, Stromelysin-1, Transin) Storage: -70°C MMP-3 catalytic domain (residues 83-255) from human cDNA, expressed in E.coli. Applications: study enzyme kinetics, cleave target substrates, and screen for inhibitors.

  • IR10 Insulin Receptor, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-Tyr-Glu-Thr-Asp-Tyr-pTyr-Arg-Lys >97%, MW=1703.0, Storage: -20°C Phosphopeptide corresponding to the insulin receptor regulatory region. Can be used as a tyrosine phosphatase substrate 1 . 1. H. Cho et al., "Prot. Science" 1993, 2: 977

  • Sb-203580

    Enzo Life Sciences

    98%, MW=377.4, Storage: -20°C 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole. Selective inhibitor of p38 mitogen-activated protein (MAP) kinase 1 . Inhibition is competitive with ATP (Ki=21 nM) 2 . Inhibits p38-MAPK stimulation of MAPKAPK2…

  • IR9 Insulin Receptor, 0.5 mg

    Enzo Life Sciences

    Thr-Arg-Asp-Ile-Tyr-Glu-Thr-Asp-pTyr-Tyr-Arg-Lys >97%, MW=1703.0, Storage: -20°C Phosphopeptide corresponding to the insulin receptor regulatory region. Can be used as a tyrosine phosphatase substrate 1 . 1. H. Cho et al., "Prot. Science" 1993, 2: 977

  • Antibiotic A-23187, 4-bromo

    Enzo Life Sciences

    98%, MW=602.5 [76455-82-8] Storage: -20°C A highly selective calcium ionophore which is a useful tool for increasing intracellular Ca 2+ concentration. A nonfluorescent analog of A-23187 (Thomas No. C002A24) and therefore useful in the presence of fluorescent probes 1 . 1. C.M. Deber…

  • Ubiquitinylation (Ubiquitin Conjugation) Kit, 50 Assays

    Enzo Life Sciences

    Store at -80°C This kit provides the means of generating a range of thioester-linked ubiquitin conjugation enzymes (E2s), utilizing the first two steps in the ubiquitin cascade; for use in the transfer of ubiquitin to E3 ligases; and the subsequent ubiquitinylation of target substrate…

  • EGF Receptor, 10 U

    Enzo Life Sciences

    (Matrix Metalloproteinase-12, Metalloelastase, Macrophage Elastase) Storage: -70°C MMP-12 catalytic domain (residues 84-255) from human cDNA, expressed in E. coli. Applications: study enzyme kinetics, cleave target substrates, and screen for inhibitors.

  • Trichostatin A, 1 mg

    Enzo Life Sciences

    99%, MW=302.4 [58880-19-6] Storage: -20°C Trichostatin A (TSA) is a potent and reversible inhibitor of histone deacetylase. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin 1 . In cells latently infected with…

  • ZM 336372

    Enzo Life Sciences

    95%, MW=389.4, Storage: -20°C Potent and specific inhibitor of c-Raf (IC50=70 nM) in vitro. It displays no significant inhibition of 20 other protein kinases except SAPK2/p38 (IC50=2 µM) 1 . ZM 336372 induces a paradoxical activation (>100 fold) of c-Raf…

  • L-a-Phosphatidylinositol-3, 4, 5 Trisphosphate, 100 ug

    Enzo Life Sciences

    Ptdlns 3, 4, 5-P3 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-tris phosphate-7(NH3) 98%, MW=1170, Storage: -20°C Activates Ca 2+ -insensitive PKC isotypes δ , ε and η 1 . Binds to GRP1 via a PH domain 2 . 1. A.…

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