Ribonuclease A (RNase A) is an endoribonuclease, that specifically cleaves single-stranded RNA 3' to pyrimidine residues (cytosine, uracil). Thereby, it generates pyrimidine-3'-phosphate or oligonucleotides with terminal pyrimidine-3'-phosphates. A major application for RNAse A is the removal of…

Rifampicin is active against gram-positive bacteria but less active against gram-negative bacteria. It interferes with the synthesis of nucleic acids by inhibiting DNA dependent RNA polymerase. Resistance to rifampicin can develop rapidly. The degree of resistance varies depending on the site of…