Protein

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  • Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the…

  • Cecropin B

    Bachem

    Cecropin B is a 35-residue peptide which showed activity against different tumor cell lines.

  • Octreotide

    Bachem

    A slow-release form of octreotide. Pamoate is the bivalent anion of pamoic acid (embonic acid, 4,4·-methylene-bis-(3-hydroxy-2-naphthoic acid)). CAS-number (octreotide pamoate): 135467-16-2.

  • N-terminally biotin-labeled Aβ40.

  • Melatonin

    Bachem

    Melatonin reverses the darkening effect (on skin) of melanotropin and inhibits LH-secretion. Shukla et al. observed that melatonin stimulates the nonamyloidogenic processing of APP via positive transcriptional regulation of ADAM10 and ADAM17 acting as α-secretases. Melatonin has been…

  • Glucagon sulfoxide shows the same maximal glucose mobilizing activity in rat hepatocytes as native glucagon, but it is less potent, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor.

  • This bombesin analog is a specific antagonist of the bombesin receptor.

  • The flexible LC spacer increases the accessibility of the biotin moiety.

  • Stable isotope-labeled orexin A analog for use as internal standard in a sensitive quantitative mass spectrometry assay of the peptide hormone in cerebrospinal fluid.

  • Anderson and Webb could verify using transmission electron microscopy that N-terminal labeling of Aβ40 with TAMRA and other fluorescent dyes does not prevent the formation of protofibrils and amyloid fibrils of various widths.

  • During heparin-induced self-aggregation of the four repeat domain peptides (R1–R4) excised from tau, R1, which resembles Tau Peptide (244-274), was the most resistive to filament formation. Its conformation remained unchanged. The peptide maintained the same random structure under both acidic…

  • An LRF-amide motif containing fragment of malignant melanoma metastasis-suppressor KiSS-1 which binds to human GPR54, a G-protein-coupled receptor also known as AXOR12. It shows lower agonistic potency towards AXOR12 than malignant melanoma metastasis-suppressor Kisspeptin-10 (H-5544).

  • Residue Lys87, contained in Tau Peptide (74-102) (Exon 3/Insert 2 Domain), is one of the glycation sites of PHF-tau in vitro.

  • Heavy isotope-labeled octreotide useful for pharmacokinetic/pharmacodynamic studies in combination with Bachem product H-5972 Octreotide and the corresponding API, H-5972-GMP.

  • Amyloid β-peptide (1-40) showed both neurotrophic and neurotoxic effects in dependence on the neuronal age and the concentration of the β-protein. Aβ 1-40 has been used as well as Aβ 1-42 to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's…

  • Control peptide for LL37.

  • Two hepcidins have been found in mice, hepcidin-1, a homolog of human hepcidin-25 in serum and hepcidin-2, a pentacosapeptide with differing sequence in urine. Hepcidin-1 could be involved in murine brain iron metabolism.

  • H-7438 was obtained by dissolving Amyloid β-Protein (1-40) (H-1194) in HFIP, aliquoting, and removing the solvent as described in the literature.

  • Heavy isotope-labeled Glucagon useful for pharmacokinetic/pharmacodynamic studies in combination with Bachem product H-6790 Glucagon (1-29) (human, rat, porcine) or the corresponding generic API (Glucagon).

  • The flexible LC spacer increases the accessibility of the biotin moiety.

  • The amphipathic helical structure of the third fragment (306-336) in the four-repeat microtubule-binding domain of the water-soluble tau protein could be responsible for the formation of the neuropathological filament.

  • Compared to the TFA salt, the HCl salt of amyloid β-protein (1-40) easily forms β-structures in PBS within a few hours at 25°C. β-structure formation is essential for amyloid peptide toxicity.

  • Cecropin P1

    Bachem

    Cecropin P1 (SWLSKTAKKLENSAKKRISEGIAIAIQGGPR), a homolog of insect cecropins isolated from pig intestine, was thought to be the first mammalian antimicrobial peptide. Later studies showed that the peptide is produced by the intestinal parasitic nematode Ascaris suum. The 31 amino acid peptide is…

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