Nucleotides, Analogs & Precursors

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MP Biomedicals Nucleotides, Analogs & Precursors

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  • Guanosine-5'-Triphosphate Disodium Salt

    MP Biomedicals

    Guanosine-5'-triphosphate, a purine nucleotide, is required as a coenzyme for protein biosynthesis in a cell-free system. Guanosine 5′-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR)…

  • ß-Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt

    MP Biomedicals

    β-NADP is a coenzyme necessary for the alcoholic fermentation of glucose and the oxidative dehydrogenation of other substances. It occurs widely in living tissue, especially in the liver. Nicotinic acid can be converted to nicotinamide in the body and, in this form, is found as a component of…

  • ß-Nicotinamide Adenine Dinucleotide Phosphate, Reduced

    MP Biomedicals

    β-NADPH is a product of the pentose phosphate pathway, a multifunctional pathway whose primary purpose is to generate reducing power in the form of β -NADPH. β-NADPH transfers H+ and 2 e- to oxidized precursors in the reduction reactions of biosynthesis. Thus, β-NADPH cycles…

  • ß-Nicotinamide Adenine Dinucleotide Phosphate Reduced Tetrasodium Salt

    MP Biomedicals

    Electron donor; cofactor for many redox enzymes including nitric oxide synthetase. β-NADPH is a product of the pentose phosphate pathway, a multifunctional pathway whose primary purpose is to generate reducing power in the form of β -NADPH. β-NADPH transfers H+ and 2 e- to…

  • Guanidine Hydrochloride

    MP Biomedicals

    Guanidine Hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins, such as inclusion bodies, and be used for the recovery of periplasmic proteins. This can be used as the first…

  • ß-Nicotinamide Adenine Dinucleotide

    MP Biomedicals

    β-NAD is one of the biologically active forms of nicotinic acid. Occurs in living cells, primarily in the oxidized state Coenzyme for dehydrogenases NAD usually acts as a hydrogen acceptor, forming NADH Major electron acceptor molecule in biological oxidations. Acts as a…

  • Uridine-5'-Diphosphoglucose Disodium Salt

    MP Biomedicals

    Uridine-5'-diphosphoglucose Disodium Salt is a biosynthetic product produced by the reaction of UTP and glucose-1-phosphate catalyzed by uridyl transferase. UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to…

  • Adenosine-5'-Triphosphate Disodium Salt Hydrate

    MP Biomedicals

    Adenosine 5'-triphosphate (ATP) disodium salt hydrate is a multifunctional nucleotide, which is essential in a variety of cellular functions. Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes:…

  • Uridine-5'-Triphosphate Trisodium Salt

    MP Biomedicals

    Uridine-5'-Triphosphate Trisodium Salt is a nucleoside diphosphate. P2Y receptor agonist Energy-rich precursor in the enzymatic biosynthesis of RNA Potent vasodilator Induces contractile responses in some tissues UTP has been used to study its vasodilatory effects on the…

  • Guanosine-5'-Triphosphate Disodium Salt

    MP Biomedicals

    Guanosine-5'-triphosphate, a purine nucleotide, is required as a coenzyme for protein biosynthesis in a cell-free system. Substrate for RNA polymerases Substrate for wide range of GTPases GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical…

  • Inosine-5-Monophosphate Disodium Salt Hydrate

    MP Biomedicals

    IMP a nucleotide produced by the deamination of adenosine monophosphate (AMP); it is the precursor of AMP and GMP in purine biosynthesis and an intermediate in purine salvage and in purine degradation. Inosine 5′-monophosphate (IMP) is used as a substrate to study the distribution,…

  • 5-Aza-2'-Deoxycytidine

    MP Biomedicals

    5-Aza-2′-Deoxycytidine has been found to induce changes in the differentiated state of cultured mouse embryo cells and additionally inhibits DNA methyltransferase (Dnmt). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors,…

  • ß-Nicotinamide Adenine Dinucleotide Reduced Disodium Salt

    MP Biomedicals

    β-NADH, a pyridine nucleotide and biologically active form of nicotinic acid, is a coenzyme necessary for the catalytic reaction of certain enzymes. β-NAD+ is a carrier for hydride ion, forming β-NADH. The hydride ion is enzymatically removed from a substrate molecule by the action…

  • 4-Thiouridine

    MP Biomedicals

    4-Thiouridine is a thiol modified ribonucleoside, in which the oxygen replaced by sulfur is that at C-4. It is a photoactivable uridine analogue used as an affinity label(An enzyme inhibitor, generally irreversible, that is similar in structure to a particular substrate for a specific enzyme) &…

  • 5-Iodo-2'-Deoxyuridine

    MP Biomedicals

    5-Iodo-2'-deoxyuridine is pyrimidine analog (halogenated thymidine) compete with thymidine for incorporation into the DNA of replicating cells. This incorporation results in radio sensitizing effects which is used in human cancer studies. 5-Iodo-2'-deoxyuridine (5-IUdR; IdUrd) is a…

  • Flavin Adenine Dinucleotide Disodium Salt

    MP Biomedicals

    Flavin adenine dinucleotide (FAD) is used as a redox cofactor (electron carrier) by flavoproteins including succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2, AMID), folate/FAD-dependent tRNA methyltransferases, and N-hydroxylating…

  • ß-Nicotinamide Adenine Dinucleotide

    MP Biomedicals

    β-NAD is one of the biologically active forms of nicotinic acid. Coenzyme of the dehydrogenases, especially in the dehydrogenation of primary and secondary alcohols Inhibitory neurotransmitter in visceral smooth muscle Acts as a hydrogen acceptor, forming NADH …

  • Guanosine

    MP Biomedicals

    Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate…

  • 5-Fluorodeoxyuridine

    MP Biomedicals

    5-Fluorodeoxyuridine is an antineoplastic agent, which acts as an antimetabolite . When administrated by rapid injection it acts as flurouracil, but when infused slowly, usually intra-arterially, it is converted to active F-dUMP, which leads to enhanced inhibition of DNA synthesis. It inhibits DNA…

  • Adenosine

    MP Biomedicals

    Adenosine is a nucleotide resulting from the union of one molecule of sugar -- d-ribose -- with a base -- l-adenine. Active in cardiovascular disorders Indicated in cases of angina pectoris Increases coronary output Vasodilator action Induced apoptosis in human leukemia HL-60…

  • Guanosine-5'-Triphosphate Trisodium Salt

    MP Biomedicals

    GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of…

  • Adenosine, USP

    MP Biomedicals

    Adenosine is a purine nucleoside comprising a molecule of adenine attached to a ribose sugar molecule moiety via a β-N9-glycosidic bond. It plays an important role in energy transfer. It is an endogenous purine nucleoside that modulates physiological process wherein cellular signaling by…

  • Uridine-5'-Triphosphate Trisodium Salt

    MP Biomedicals

    UTP has been used as a P2 receptor activator to study its effects on proton efflux in MC3T3-E1 and UMR-106 cells. UTP has also been studied in combination with amiloride hydrochloride in nebulizer solutions for treating cystic fibrosis. P2Y receptor agonist. Note: the items below have a Dry…

  • Uridine

    MP Biomedicals

    Uridine is one of the four basic components of ribonucleic acid (RNA); the other three are adenosine, guanosine, and cytidine. Upon digestion of foods containing RNA, uridine is released from RNA and is absorbed intact in the gut. Uridine plays a role in the glycolysis pathway of galactose. …

  • Adenosine-5'-Triphosphate Disodium Salt Hydrate

    MP Biomedicals

    P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems. Adenosine 5'-triphosphate (ATP) and its phosphate bonds are the basic components of energy exchange in many biological systems.

  • Isopropyl-ß-D-Thiogalactopyranoside

    MP Biomedicals

    IPTG (isopropyl-β-thiogalactoside) is an analogue of allolactose that binds specifically to the repressor protein of the lac operon and induces expression of β-galactosidase in Escherichia coli. IPTG is a commonly used reagent in cloning procedures that require induction of…

  • Uracil

    MP Biomedicals

    Used in drug delivery and in pharmaceuticals. In addition to this, it is used in the synthesis of caffeine and in the determination of microbial contamination of tomatoes. Uracil is produced by hydrolysis of nucleic acid and used in biochemical research. It serves as a allosteric regulator and…

  • Ribonucleic Acid from Torula Yeast

    MP Biomedicals

    Ribonucleic acid (RNA) from torula yeast may be used as a substrate for studying ribonuclease activities of enzymes such as ribonuclease-A, ribonuclease T1 (RNAase) and bougainvillea xbuttiana antiviral protein 1 (BBAP1).

  • Adenosine-5'-Diphosphate Monopotassium Salt Dihydrate

    MP Biomedicals

    Adenosine 5′-diphosphate is a P2Y receptor agonist. Adenosine 5′-diphosphate has been used to study the release, neuronal effects and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. Adenosine 5′-diphosphate has also been used to…

  • 5-Chloro-2'-Deoxyuridine

    MP Biomedicals

    5-Chloro-2'-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. 5-Chloro-2′-deoxyuridine (CldU) is used as a thymidine analogue to study the miscoding potential of hypochlorous acid damage…

  • 5-Phosphorylribose-1-Pyrophosphate Sodium Salt Hydrate

    MP Biomedicals

    5-Phosphorylribose-1-pyrophosphate Sodium Salt Hydrate has been used in a study to assess the relationship between the muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells. It has also been used in a study to investigate inhibitors of the bacterial…

  • Deoxyribonucleic Acid Sodium Salt from Salmon or Herring Sperm

    MP Biomedicals

    Deoxyribonucleic Acid is a polynucleotide . It is an essential component of chromosomes in cell nuclei. It is the carrier of genetic material. It contains information in chemical code to direct the development of the cell according to its inheritance. The purine and pyrimidine bases of the…

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