Enzymes & Inhibitors, 50 mg
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AEBSF (4-(2-Aminoethyl)benzenesulfon
bioWORLDInhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin and other related thrombolytic enzymes. Less toxic substitute for PMSF. Specific and irreversible inhibitor of serine proteases. Synonym: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride pKb: 9.19 (Predicted) …
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Papain from Papaya Latex
MP BiomedicalsPapain is a sulfhydryl protease from Carica papaya latex. Cleaves peptide bonds of basic amino acids, leucine, or glycine Hydrolyzes esters and amides One unit will hydrolyze 1.0 µmole of N-alpha-benzoyl-L-arginine ethyl ester (BAEE) per minute at 25°C and pH 6.2 Papain…
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4-(2-Aminoethyl)-Benzenesulfonyl Fluoride Hydrochloride
MP BiomedicalsAEBSF hydrochloride is a covalent binding serine protease inhibitor, belongs to the family of irreversible sulfonyl fluoride inhibitors that block trypsin and chymotrypsin-type enzymes. Similar in structure to the commonly used inhibitor PMSF, AEBSF offers better solubility in water, lower…
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Trypsin, TPCK-treated
bioWORLDProtease which cleaves specifically at the -COOH side of arginie and lysine. TPCK-treated Trypsin is a serine endopeptidate Trypsin is treated with TPCK to inactivate any remaining chymotryptic activity This type of trypsin is modified by acetyltion of the sigma-amino groups of lysine…
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a-Amylase from Porcine Pancreas
MP Biomedicalsα-Amylase isolated from porcine pancreas is a glycoprotein. It is a single polypeptide chain of ~475 residues containing two SH groups and four disulfide bridges and a tightly bound Ca2+ necessary for stability. Chloride ions are necessary for activity and stability. α-Amylase is…
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Elastase from Porcine Pancreas
MP BiomedicalsElastase is an enzyme from the class of proteases (peptidases) that break down proteins. It hydrolyzes peptide bonds, especially those adjacent to neutral amino acids. Hydrolyses elastin Digests hemoglobin, casein, and fibrin One unit will solublize 1 mg of elastin in 20 minutes at…
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Resveratrol
MP BiomedicalsPotent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2…
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Ribonuclease A from Bovine Pancreas
MP BiomedicalsRibonuclease belongs to pancreatic ribonuclease family. RNase A is an endoribonuclease that attacks at the 3¢ phosphate of a pyrimidine nucleotide. The sequence of pG-pG-pC-pA-pG will be cleaved to give pG-pG-pCp and A-pG. Ribonuclease A is used to remove RNA from DNA plasmid preparations…
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Genistein
MP BiomedicalsCell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Inhibitor of mammalian DNA topoisomerase II. Anticancer agent, inducing cell cycle arrest and apoptosis.…
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Resveratrol (synthetic)
MP BiomedicalsPotent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2…
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Daunomycin Hydrochloride from Streptomyces peucetius
MP BiomedicalsAn antineoplastic of Rhodomycin group; Antibiotic; Inhibitor of enzymes and metabolic pathways. A potent anticancer agent that has been shown to be a strong inhibitor of DNA and RNA synthesis. Daunorubicin hydrochloride is used in photostability , antileukemic, and drug metabolism studies. …
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Orlistat
MP BiomedicalsHypolipemic cell permeable and irreversible pancreatic, gastric and carboxylester lipase inhibitor. Anti-obesity and antihypercholesterolemic compound. Antitumor compound by inhibition of the thioesterase domain of fatty acid synthase (FASN). Anti-proliferative. Causes cell cycle arrest at G1…
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Acetoacetyl Coenzyme A Trisodium Salt Tetrahydrate
MP BiomedicalsAcetoacetyl coenzyme A (Acetoacetyl-CoA) may be used as a substrate for a number of enzymes including; acetoacetyl-CoA thiolase (EC 2.3.1) which produces acetyl-CoA in reverse condensation reaction and (3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS)) which produces…
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Ribavirin
MP BiomedicalsRibavarin is an antiviral compound reported to be active against RSV, HIV, HCV and other infectious agents. Its metabolite, ribavirin 5'-phosphate, inhibits inosine monophosphate dehydrogenase (IMP). It is also an analog of the imidazole nucleotide intermediates in purine nucleotide…
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Cytochalasin B from Helminthosporium dematioideum
MP BiomedicalsCell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport. One of a group of fungal metabolites that interfere with a wide…
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L-Glutamic Dehydrogenase from Bovine Liver
MP BiomedicalsL-glutamic dehydrogenase is a pyridine nucelotide enzyme which catalyzes the reversible oxidative deamination of L-glutamate to α-keto-glutarate and ammonia. L-glutamic dehydrogenase plays a unique role in mammalian metabolism. The reverse reaction catalyzed by this enzyme is the only pathway…
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Forskolin
MP BiomedicalsPotent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis…
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Demecolcine
MP BiomedicalsDemecolcine, also known as colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. Demecolcine is an antineoplastic agent used to immobilize chromosomes by…
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D-Luciferin (free acid)
bioWORLDAlso known as 4,-5-Dihydro-2-(6-hydroxyl-2-benzo-thiazoyl)-4-thiazole-carboxylic acid. Used with firefly luciterase in bioluminiscence for the determination of ATP.