Enzymes & Inhibitors, 1 mg
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MBIMPH F-Analog 1 . hydrochloride
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and…
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MBIMPH F-Analog 2
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and…
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Paclitaxel
MP BiomedicalsAnticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle…
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Phorbol-12-Myristate-13-Acetate, 1 Mg
MP BiomedicalsPMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
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Staurosporine
G-BiosciencesStaurosporine is a strong inhibitor of phosphalipid/Ca2+ dependent protein kinase and platelet aggregation. It is most commonly used as an inducer of apoptosis in several mammalian cell types. It is also used to study role of protein kinases in signal transduction as it inhibits other protein…
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Cytochalasin B
MP BiomedicalsCell permeable mycotoxin. Actin polymerization inhibitor. Binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. Induces nuclear extrusion. By disrupting actin polymerization, blocks diverse cellular functions, including cell division, migration,…
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Acetyl Coenzyme A Trilithium Salt Trihydrate
MP BiomedicalsAcetyl-CoA is produced via beta-oxidation of fatty acids, via the metabolism of carbohydrates - glucose 6-phosphate to pyruvate to acetyl-CoA and via the catabolism of amino acids. Acetyl-CoA has a number of metabolic opportunities. It is metabolized in the tricarboxylic acid cycle to produce…
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a-Thrombin from Bovine
MP Biomedicalsα-Thrombin from Bovine Plasma is highly specific serine protease. Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects. Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible…
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Protease from Staphylococcus aureus V8 Strain
MP BiomedicalsProtease from Staphylococcus aureus strain V8 is composed of a single polypeptide chain. The Staphylococcus strain V8 protease specifically cleaves peptide bonds on the carboxyl (COOH) terminal side of aspartic and glutamic acid residues. Protease V8 is used for selective cleavage of proteins…
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Thiocolchicoside
MP BiomedicalsPotent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through…
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Z-Val-Glu(OMe)-Ile-Asp(OMe)-Fluoromethylketone
MP BiomedicalsZ-Val-Glu(OMe)-Ile-Asp(OMe)-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Z-Val-Glu(OMe)-Ile-Asp(OMe)-FMK used for both in vitro and in vivo studies. If the…
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Z-Val-Ala-Asp-(OMe)-Fluoromethylketone
MP BiomedicalsThe novel Z-VAD(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds to activated Caspases to block apoptosis. Apoptosis is a physiological form of cell death, which plays an important role in embryogenesis, cellular homoestasis, tissue atrophy, and…
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MBIMPH
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and…
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Daunomycin Hydrochloride from Streptomyces peucetius
MP BiomedicalsAn antineoplastic of Rhodomycin group; Antibiotic; Inhibitor of enzymes and metabolic pathways. A potent anticancer agent that has been shown to be a strong inhibitor of DNA and RNA synthesis. Daunorubicin hydrochloride is used in photostability , antileukemic, and drug metabolism studies. …
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SG-Carboxypeptidase B (Recombinant)™
G-BiosciencesSG-Carboxypeptidase B (Recombinant)™is the rat carboxypeptidase B expressed in E. coli. Carboxypeptidase B specifically hydrolyses basic amino acids including lysine, arginine and histidine from the C-terminal end of polypeptides. It is used in sequencing protein and peptides. Other…
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DABPH
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =12nM). Displays high selectivity over HDAC1 (IC50=6.8µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation.…
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Leupeptin Hemisulfate
MP BiomedicalsLeupeptin is a modified tripeptide reversible protease inhibitor of trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, kallikrein, papain, thrombin, cathepsin B, cathepsins H and L, trypsin, calpain, trypsin8 and plasmin. Effective concentration is typically 10-100…
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Acetoacetyl Coenzyme A Trisodium Salt Tetrahydrate
MP BiomedicalsAcetoacetyl coenzyme A (Acetoacetyl-CoA) may be used as a substrate for a number of enzymes including; acetoacetyl-CoA thiolase (EC 2.3.1) which produces acetyl-CoA in reverse condensation reaction and (3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS)) which produces…
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Pepstatin A
MP BiomedicalsPepstatin A is a reversible inhibitor of aspartic proteases, Inhibitor for pepsin, renin, cathepsin D, cathepsin G, and other acid proteases. It does not inhibit thiol proteases, neutral proteases or serine proteases. Pepstatin forms a 1:1 complex with acid proteases (carboxyl proteases). …
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FITC-Val-Ala-Asp(Ome)-FMK
MP BiomedicalsFITC-Val-Ala-Asp(OMe)-FMK is an inhibitor for General Caspases.
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Cytochalasin B from Helminthosporium dematioideum
MP BiomedicalsCell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport. One of a group of fungal metabolites that interfere with a wide…
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BOC-ASP(OMe)-FMK
MP BiomedicalsThe FMK peptides are potent, cell permeable, irreversible inhibitors. It is useful for in vitro and in vivo applications. BOC-ASP(OMe)-FMK is an inhibitor for general Caspases. The novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds…
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DMAPB
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =114nM). Displays selectivity over other HDACs (IC50=1-8µM). Neuroprotective and anti-neuroinflammatory agent. Reduced neuronal degeneration after traumatic brain injury (TBI). Shown to increase histone H3 acetylation. HDAC6…
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E-64 from Synthetic
MP BiomedicalsE-64 is an inhibitor for thiol protease, papain, actinidin, ananain, bromelain, calpain and cathepsin B. It is an irreversible cysteine protease inhibitor that has no action on cysteine residues in other plants and does not react with low molecular weight thiols such as 2-mercaptoethanol. Specific…
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Forskolin
MP BiomedicalsPotent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis…
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PMPH
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation.…
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Demecolcine
MP BiomedicalsDemecolcine, also known as colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. Demecolcine is an antineoplastic agent used to immobilize chromosomes by…
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Q-VD-Oph
MP BiomedicalsThe novel Q-VD-OPH compound synthesized using proprietary technology is an irreversible caspase inhibitor specifically designed for in-vivo research.The Q-VD-OPH irreversibily binds to activated Caspases to block apoptosis. Apoptosis is a physiological form of cell death, which plays an important…