Allyl disulfide is an organosulfur originally found in garlic that exhibits antioxidative, antiviral, neuroprotective, anti-parasitic, anticancer, and anti-hyperlipidemic activities. Allyl disulfide induces phase II enzymes, inhibits lipid peroxidation, and acts as a radical scavenger. In vitro,…

An organosulfur compound derived from allicin; converted, in the presence of thiols, to the gaseous mediator H2S; serves as a thiol-dependent H2S donor in biological systems.

A natural alkaloid that blocks potently inhibits MEK-1 (IC₅₀ = 9 nM); also inhibits numerous kinases in vitro, most notably GSK3β, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC₅₀s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2, several…

A competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes metabolism of ethylene glycol and methanol to toxic metabolites; typically used as an antidote for ethylene glycol or methanol poisoning.