Biologically Active Small Molecules, LKT Labs, 5 mg
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Citrinin
LKT LabsCitrinin is a mycotoxin initially produced by Penicillum, Aspergillus, and Monascus. Citrinin exhibits cytotoxic, cardiotoxic, nephrotoxic, and pro-oxidative activities. In leydig cells, citrinin inhibits testosterone production and induces caspase-mediated apoptosis. In embryos, citrinin alters…
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Brevetoxin 2
LKT LabsBrevetoxins are lipid-soluble polyether neurotoxins initially produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening…
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Actinomycin
LKT LabsActinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…
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Bromosporine
LKT LabsBromosporine is an inhibitor of BET bromodomains (BRDs) BRD2, BRD4, BRD9, and CECR2; it may exhibit anticancer potential.
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A grasshopper neuropeptide from a family of arthropod hormones and neuroregulators, found in Locusta migratoria.
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Adipokinetic Hormone, locust
LKT LabsAdipokinetic hormone is a neuropeptide hormone found in insects that is involved in the regulation of circadian rhythms. Adipokinetic hormone also increases activity of peptidase, lipase, amylase, and polygalacturonase in the salivary glands. In brain samples treated with H2O2, this peptide…
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Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…
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Bursin
LKT LabsBursin is a tripeptide that induces B-cell differentiation. Bursin’s immunostimulatory activity allows it to be used as an adjuvant for immunizations. Grade: ≥95%
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Chromomycin A3
LKT LabsChromomycin A3 is an anthraquinone that exhibits antibacterial and anticancer chemotherapeutic activity. Chromomycin A3 binds Mg2+ and Zn2+ ions, and these complexes bind GC sequences in nucleosomal DNA; this inhibits DNA gyrase, RNA polymerase, and DNA transcription. Chromomycin inhibits growth of…
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AZD-4547
LKT LabsAZD-4547 is an inhibitor of FGFR that is somewhat selective for FGFR2 over FGFR1 and FGFR3; it exhibits anticancer chemotherapeutic activities. This compound is currently in clinical trials as a potential treatment for breast cancer. In breast cancer cells, AZD-4547 induces apoptosis and inhibits…
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Chymostatin
LKT LabsChymostatin is an inhibitor of proteases such as chymase that is used in research models.
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Actinonin
LKT LabsActinonin is an inhibitor of peptide deformylase, matrix metalloproteinase meprin A, and aminopeptidase N (CD13). Actinonin exhibits anticancer, antibiotic, anti-inflammatory, and nephroprotective activities. In Burkitt’s lymphoma cells, actinonin inhibits mitochondrial protein translation,…
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Ciglitazone
LKT LabsCiglitazone is a thiazolidinedione that exhibits antihypertensive, anticancer, and anti-diabetic activities. Ciglitazone acts as an agonist at PPAR? receptors, decreasing insulin levels, VEGF production, and blood pressure. In cellular models of stomach cancer, ciglitazone induces G1 phase cell…
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Citreoviridin A
LKT LabsCitreoviridin A is a mycotoxin found in cereal and bread grains; it exhibits pro-oxidative, anticancer chemotherapeutic, antibacterial, antifungal, and antiviral activities. In vitro, citreoviridin A increases ROS levels and decreases glutathione, inducing oxidative stress, destabilizing the…
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This compound is a conjugate of N-acetyl-cysteine and sulforaphane. Like other isothiocyanates (ITCs), this compound likely displays antioxidative activity. Grade: ≥98%
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Buccalin
LKT LabsBuccalin is a neuropeptide found in mollusks. Buccalin modulates neuromuscular transmission and decreases motor neuron-induced muscular contractions.
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Butein
LKT LabsButein is a flavonoid originally found in the bark of Rhus verniciflua and the flowers of Butea monosperma. Butein exhibits anticancer chemotherapeutic, anti-angiogenic, neuroprotective, anti-inflammatory, antioxidative, and anti-fibrotic activities. In lung cancer cells, butein decreases…
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Adrenocorticotropic Hormone (1-4)
LKT LabsAdrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…
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BX-795
LKT LabsBX-795 inhibits PDK1, exhibiting anticancer chemotherapeutic activity. BX-795 inhibits Akt signaling, inducing apoptosis and suppressing tumor growth. Grade: ≥98%
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Adrenomedullin (1-52), human
LKT LabsAdrenomedullin is an endogenous peptide hormone involved in growth and differentiation of stem cells. This peptide exhibits vasodilatory, natriuretic, and cardioprotective activities. Adrenomedullin decreases blood pressure and increases neovascularization. This peptide binds microtubule-associated…
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Adrenocorticotropic Hormone (1-14)
LKT LabsAdrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…
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Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…
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Adipokinetic Hormone
LKT LabsAdipokinetic hormone is a neuropeptide hormone found in insects that is involved in the regulation of circadian rhythms. Adipokinetic hormone also increases activity of peptidase, lipase, amylase, and polygalacturonase in the salivary glands. In brain samples treated with H2O2, this peptide…
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Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…
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Brevetoxin 3
LKT LabsBrevetoxins are lipid-soluble polyether neurotoxins initially produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening…
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Cinacalcet Hydrochloride
LKT LabsCinacalcet is an agonist at Ca2+-sensing receptors that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. This compound decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, and lowers…