Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Diabetagen Toxic to pancreatic islet insulin-producing β-cells Toxic to GLUT2 psoitive neuroendocrine tumor cells Streptozocin is used to…

Protein Kinase C inhibitor. Tamoxifen Citrate Salt is a nonsteroidal triphenylethylene derivative. Tamoxifen and its metabolite 4-hydroxytamoxifen are mixed estrogen agonists/antagonists. Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in…

Ivermectin is a macrolide antiobiotic, & semisynthetic derivative of avermectin B1a and B1b. Ivermectin is a broad-spectrum antiparasitic agent. Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. It has no significant activity against other Gram-negative bacteria and very limited activity against Gram-positive bacteria and anaerobic bacteria. Cefuslodin is most…

Morin is a flavonoid with anti-oxidant properties. Morin hydrate is a flavonoid with antioxidant properties. It has been shown to protect cells against oxygen radical damage. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase, a free-radical generating enzyme. At…

Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. Hygromycin has been used to select drug-resistant stable transfectants after transfer of the hygromycin…

Doxorubicin Hydrochloride is a chemotherapeutic, antitumor, immunosuppressive, and antibiotic agent. Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis. Naturally fluorescent anthracycline antibiotic,…

Kanamycin sulfate is an antimicrobial agent effective against Gram-negative and Gram-positive bacteria and mycoplasma. It binds to the 70S ribosomal subunit, inhibits translocation, and elicits miscoding. Cross-resistance occurs between kanamycin and neomycin, framycetin, and paromomycin, and…

Kanamycin is an aminoglycoside antibiotic effective against mycoplasma, gram-positive and gram-negative bacteria. It is used in biotechnology applications to inhibit protein synthesis. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial…

Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation. Protein kinase C inhibitor (IC50 = 50-200 µM depending on assay conditions in MCF-7 cells or…

Paromomycin Sulfate is an aminoglycoside antibiotic which inhibits protein initiation. Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against Gram-negative…

Hygromycin B is an antibiotic substance isolated from Streptomyces hygroscopicus. Its mode of action is the inhibition of protein synthesis, by inducing the misreading of the m-RNA template in the prokaryote, (E. coli, at 100 mg/mL), lower eukaryotes (e.g., yeast, at 200 mg/mL) and higher…

Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII.…

Cycloheximide is a glutarimide antibiotic derived from a microbial source. Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. Control of various molds and fungi in…

Chloroquine Diphosphate salt is a member of the quinolone family and a lysosomotropic agent (accumulate inside the acidic parts of the cell). This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes. Chloroquine…

≥90%, Clear Gel CAS Number: 56092-81-0 Molecular Formula: C₄₁H₇₂O₉ Molecular Weight: 709.0 Ionomycin is highly selective calcium ionophore. Ionomycin is a polyether antibiotic produced by Streptomyces conglobatus. Applications …

Cell Culture Reagent, White Powder CAS Number: 69-52-3 Molecular Formula: C₁₆H₁₈N₃O₄SNa Molecular Weight: 371.4 Ampicillin sodium salt is a semi-synthetic derivative of penicillin, active as a broad-spectrum antibiotic. It is inactivated by…

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits…

Antibiotic. Antibacterial against Gram positive and Gram negative bacteria. Exhibits chemotherapeutic activity. Blocks tumor cell invasion and restores cancer cell susceptibility to apoptosis in vitro. Uncouples vacuolar ATPases, inhibiting autophagy and tumor growth. Antimalaria, antifungal and…

Nystatin is an antifungal antibiotic obtained from Streptomyces noursei. It is known to be a mixture, but the composition has not been completely elucidated. Nystatin A is closely related to amphotericin B. Each is a macrocyclic lactone containing a ketal ring, an all-trans polyene system, and a…

Cefoperazone sodium salt is a broad spectrum third generation cephalosporin antibiotic that has similar antimicrobial activity to ceftazidime. It is active against Pseudomonoas aeruginosa and it has enhanced activity against Enterobacteriaceae and Bacteroides sp. in the presence of the…

Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. Inhibits peptide synthesis in eukaryotic organisms Used in protein synthesis in apoptosis Study of disease resistance in plant research Cycloheximide (CHX) is an antibiotic…

Sulfanilamide is a molecule containing the sulfonamide functional group attached to an aniline. As a sulfonamide antibiotic, it functions by competitively inhibiting (i.e., by acting as a substrate analogue) enzymatic reactions involving para-aminobenzoic acid (PABA). PABA is needed in enzymatic…

Chlorhexidine digluconate, a bis(biguanide) family cationic broad spectrum antibiotic is an antiseptic and disinfectant agent. It is effective against a wide range of bacteria, some fungi and some viruses, and an agent for the prevention of gingivitis. Chlorhexidine digluconate solution inhibits…

G418 Sulfate is used as a selective antibiotic in the concentration range of 100 - 200 µg/mL for bacteria, or 200 – 500 µg/mL for most mammalian cells. It is also used for the selection of transfected mammalian cells, yeast, dictyostelium, plant and bacteria. G418 Sulfate is an…

2-Methylisothiazolone (MIT) are chemical compounds used as highly effective biocidal agents against fungal and bacterial species. They are widely used as a preservative in cosmetic industry, and as a pesticide, e.g. in paints and water tanks. 2-Methylisothiazolone (MIT) shows a broad efficiency…

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug…

Amoxicillin is an antibacterial agent against gram-positive and gram-negative bacteria. Amoxicillin is a moderate-spectrum, β-lactam antibiotic. Amoxicillin is one of the most common antibiotics prescribed for children. It is used to study the oxygen dependent antimicrobial systems of…

Novobiocin is an antibiotic produced by Streptomyces nieveus. For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used to study heat shock protein…

This triple antibiotic solution contains penicillin (10,000 IU/mL), streptomycin (10 mg/mL), and amphotericin B (25 μg/mL). Applications Penicllin-Streptomycin-Amphotericin B is used to supplement cell culture media. It is effective against yeast, fungi, gram-positive and gram-negative…

Nisin is a polycyclic lantibiotic produced by Lactococcus lactis. It is commonly used as a food preservative. It is used as a selective agent in cell culture for the isolation of gram-negative bacteria, yeast, and moulds. This is used in bioassays to study posttranslational modification of nisin.…

Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol…