Hygromycin B: Hygromycin B, an aminoglycoside antibiotic, inhibits the growth of prokaryotic and eukaryotic microorganisms and mammalian cells. It inhibits protein synthesis at the translocation step on the 70S ribosome and induces misreading of mRNA template.1-3 Hygromycin B has been used to…

G 418 sulfate: G 418 is an aminoglycoside antibiotic similar in structure to gentamycin. It exhibits toxicity towards both eukaryotic and prokaryotic cells. The optimal concentration for selection and maintenance must be determined for each cell line. For bacteria and algae, concentrations…

Polymyxin B sulfate: Polymyxin B sulfate (PMB) is a strongly cationic cyclic polypeptide antibiotic isolated from fermentation of Bacillus polymyxa. PMB is a variable mixture of B1 and B2 (predominantly B1). Polymyxins combine with cell membranes and disrupt normal permeability to small…

Amphotericin B (5mg/ml)

Trimethoprim

Nystatin: Nystatin is a fungistatic and fungicidal polyene antibiotic, which increases the permeability of the cell membrane of sensitive fungi by binding to sterols, chiefly ergosterol. Its main action is against Candida species. It is also effective against Aspergillus, Coccidioides immitis,…

Amphotericin B: Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. It has a high affinity for sterols, primarily ergosterols, of fungal and bacterial cell membranes. After binding to sterols, it forms channels in the membranes, causing small molecules to leak out. Amphotericin…

Tetracycline hydrochloride: Tetracyclines possess a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. The bacterial ribosome is the site of action of tetracyclines. Access to the ribosomes of gramnegative bacteria is obtained by passive diffusion through…

Cyclosporin A: Cyclosporin A (CsA) is a non-polar cyclic oligopeptide metabolite from the fungus Tolypocladium inflatum. It has to narrow a spectrum of antifungal activity to be very useful as an antibiotic, but it possesses potent immunosuppressive properties, affecting primarily Tlymphocytes. It…

Rifampicin: Rif is a semisynthetic derivative of rifamycin B and belongs to the rifamycin group of antibiotics. It functions as a bacteriostatic agent by interfering with the synthesis of nucleic acids by inhibiting microorganisms. The chemical, biological properties, activity studies…

Refrigeration Requirements: Refrigerator CL990-cin: CL990-cin is a selection antibiotic that acts on both eukaryotic and prokaryotic cells. Resistance to CL990-cin is conferred by the Sh ble gene from Streptoalloteichus hindustanus1-3. CL990-cin is the commercial name for a special formulation…