Puromycin is an antibiotic of unique structure and biological activity. It is produced by fermentation using Streptomyces albo-niger. There are four aspects of puromycin's biological activity that are 1) antitumor effect; 2) nephrotoxic action; 3) inhibition of purine and/or protein synthesis…

Spectinomycin is an aminocyclitol antibiotic, closely related to the aminoglycosides, it inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin. Specinomycin is used in cell…

Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S…

Penicillin G also known as benzylpenicillin. It exert a bacteriocidal as well as a bacteriostatic effect on susceptible bacteria by interfering with the final stages of the synthesis of peptidoglycan, a substance in the bacterial cell wall. Penicillin G is a narrow spectrum antibiotic derived…

Polymyxin B Sulfate is a mixture of Polymyxin B1 and Polymyxin B2 Sulfate, obtained from Bacillus polymyxia strains. Polymyxin B inhibits gram-negative organisms in vitro and is also reported to inhibit Ca2+ dependent protein kinase C (PKC). It binds to and interferes with the permeability of the…