Mode of action and Anti-microbial spectrum Rapamycin, a macrocyclic triene antibiotic, possesses immunosuppressant, anti-proliferative, and anti-cancer activity. Inhibition by rapamycin results in cell cycle arrest in G1. Rapamycin also has been shown to have a role in life span extension in…

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits…

Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the mammalian target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an alternative to calcineurin…