Thermo Scientific™ HyPURITY ADVANCE™ HPLC columns combine the outstanding performance of our HyPURITY 190A° silica with a C8 reversed phase chemistry. This specialized packing with polar embedded character is well suited for LC/MS applications. The polar group protects the surface silanols from interaction with polar analytes and provides an alternate selectivity with excellent performance for compounds showing poor peak shape with traditional alkyl bonded phases such as C18.