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MilliporeSigma

TACE, human, recombinant, expressed in insect cells, >=90% (SDS-PAGE)

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Synonyms: ADAM17; CD156b; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease; TNF-alpha convertase

Purity: >=90% (SDS-PAGE)

Storage: -70C

UNSPSC Code: 12352200

General description: A disintegrin and metallopeptidase domain 17 (ADAM17) belongs to ADAM family of genes, which has a characteristic cysteine rich region called disintegrin and a metalloproteinase domain. This gene is located on chromosome 2, spans 55kb and has 19 exons. In adult humans, ADAM17 is expressed in multiple tissues such as, heart, muscle, kidney, placenta, pancreas, thymus, small intestine, ovaries, testes and prostate. In fetus, it is expressed in brain, lung, liver and kidney.

Biochem/physiol Actions: ADAMs (A disintegrin and metallopeptidases) are called ectodomain sheddases and ADAM17 is an angiotensin-converting enzyme 2 (ACE2) sheddase. It also processes and sheds multiple cell surface molecules such as, adhesion molecules and cytokines. It produces the soluble form of tumor necrosis factor +¦ (TNF-+¦), along with the processing of I-CAM (cell adhesion molecule), V-CAM, IL-6R, L-selectin etc. These in turn play a role in development, regeneration and inflammation of the circulatory system. Polymorphism rs12692386 in ADAM17 gene is associated with an increased susceptibility to abdominal aortic aneurysm. This gene is also up-regulated in myocardial infarction patients, as well as in atherosclerosis patients. It also plays a role in the pathophysiology of ischemic strokes (IS). ADAM17 aids in tumor progression by facilitating tumor proliferation and invasion, as in the case of non-small cell lung cancer (NSCLC).

Physical form: The untagged rh-TACE (TNF-alpha converting enzyme) is supplied as a lyophilized powder.

Reconstitution: With sterile deionized water at 0.1 mug protein/muL.

Preparation Note: Centrifuge the vial prior to opening.

RIDADR: NONH for all modes of transport

WGK Germany: 3

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Product Detail
Thomas No.
C905Q94
Mfr. No.
SRP6178-20UG
Description
TACE HUMAN 20UG
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Product C905Q94 is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

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