ThermoSafe's high performance polyurethane insulated shipping containers meet the needs of the most demanding temperature-sensitive payloads. -Durable poly boxes -Protective shock absorption and cushioning -Ideal for temperature-sensitive items and long-range journeys These poly shippers protect highly temperature-sensitive shipments from moderate and extreme ambient temperature exposure Durable one-piece closed-cell polyurethane foam insulated shippers are CFC and HCFC-free and comply with international clean air regulations. Proprietary process laminates highly efficient insulation core to inner and outer corrugate walls. Withstands crush compression in excess of 5,000 lbs. Flexible polyurethane foam plug seals the top, cushions and insulates contents, and vents dry ice. R-value is + 1.5 times EPS R-value, per inch of thickness. The polyurethane insulation offers greater insulating power than equivalent thicknesses of EPS containers. Thick walls and 200 lb. outer corrugate offer protective shock absorption and cushioning during shipping and handling and provide extensive protection for long-range journeys.