A Solid Start to SPE
The Microlute™ CP hybrid technology is composed of a solid interconnected network of evenly distributed pores immobilized with chromatographic media within the structure. This results in the formation of a chemically active porous filter or frit, a unique structure that overcomes common inconsistencies and variances often associated with loose-packed methods. The porous properties of Microlute™ CP allows for consistent and controlled flow of samples throughout the filter, leading to enhanced retention and recovery of precious analytes without any risk of material breakthrough. Meanwhile, the single solid structure eliminates the requirements of ‘extra’ frits for media support which can further disrupt flow rates and lead to unwanted material breakthrough.
The synergy between structure and performance leads to a new method of SPE that promises quality performance with the added benefit of true reproducibility and reliability.
Weak Cation Exchange
Weak cation exchange is used to retain strongly basic compounds which are always ionized at any pH. The Microlute™ CP WCX uses a carboxylic acid ligand with a pKa ~4.5 which allows ionization and neutralization of the resin to allow retention and controlled release of the strong basic compounds. This is combined with the polymeric base to allow a degree of neutral compound retention.