Resprep® vacuum manifolds for SPE sample preparation, filtration, and elution are available in 12- and 24-port configurations. These manifolds help in achieving consistent extraction and filtration results. Multiple sample processing with these manifolds simplifies procedures and saves time. The manifolds consist of a clear glass chamber and lid to which vacuum is applied, drawing a sample through an SPE column, cartridge, or disk. Adjustable racks placed in the glass vacuum chamber accommodate a variety of sample collection vessels, including test tubes, autosampler vials, volumetric flasks, and Erlenmeyer flasks. SPE columns or cartridges can be plugged into the flow control valves for conditioning, sample loading, washing, drying, and elution steps. Eluants are deposited directly into the collection vessel of choice via PTFE sample guide needles.