Synonyms: 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide dihydrochloride; Y 39983; Y39983
Molecular Formula: C16H16N4O · 2HCl
Molecular Weight: 353.25
Linear Structural Formula: C16H16N4O · 2HCl
MDL Number: MFCD00945328
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Y-39983 is a potent and selective Rho-kinase (ROCK) inhibitor (IC50s = 3.6 nM). Y-39983 is 10 fold more potent in promoting the outgrowth of neurites in cultured retinal slices and axonal regeneration in crushed optic nerve models than Y-27632. Y-39983 act also as an activator of the neuroprotective Parkin-mediated mitophagy pathway.