Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms.
Vitamin B12 plays a role in the synthesis of myelin. It is a cofactor for two enzymes, methionine synthase and L-methylmalonyl-CoA mutase. The compound is also used as an antipernicious anemia factor.
Biosynthesis of the basic structure of the vitamin is accomplished only by bacteria(which usually produce hydroxocobalamin). Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.
Key Applications: Antipernicious anemia factor, Cofactor, Treatment of vitamin B12 deficiency, cyanide poisoning, and hereditary deficiency of transcobalamin II
Product Type: Biochemicals
Melting Point: >300°C(Lit.)
Presentation: Red Powder
Loss on Drying: ≤12%
Solubility: Soluble in alcohol; slightly soluble in H2O.
Storage & Handling: Store at +4°C, desiccate.