Synonyms: LY 573636; LY-573636; LY573636; N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide; N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide; N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide
Molecular Formula: C11H6BrCl2NO3S2
Molecular Weight: 415.11
Linear Structural Formula: C11H6BrCl2NO3S2
MDL Number: MFCD11973637
Purity: >=98% (HPLC)
Biochem Physiol Actions: Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) that bridges RNA binding motif protein 39 (RBM39; CAPERα, HCC1) and DCAF15 for interaction, thereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC50 = 6.5 μM), but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM.