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MilliporeSigma

Tasisulam >=98% (HPLC)

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Synonyms: LY 573636; LY-573636; LY573636; N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide; N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide; N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide

Molecular Formula: C11H6BrCl2NO3S2

Molecular Weight: 415.11

Linear Structural Formula: C11H6BrCl2NO3S2

MDL Number: MFCD11973637

Purity: >=98% (HPLC)

Storage: 2-8C

Biochem Physiol Actions: Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) that bridges RNA binding motif protein 39 (RBM39; CAPERα, HCC1) and DCAF15 for interaction, thereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC50 = 6.5 μM), but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM.

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Product Detail
Thomas No.
CHM03J611
Mfr. No.
SML2952-5MG
CAS #
519055-62-0
Description
SML2952-5MG, Tasisulam >=98% (HPLC)

list price/quantitytotal
$0.00
Thomas No.
CHM03J612
Mfr. No.
SML2952-25MG
CAS #
519055-62-0
Description
SML2952-25MG, Tasisulam >=98% (HPLC)

list price/quantitytotal
$0.00
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