This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034 (ISO Guide 34). This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.Download your certificate at: http://www.sigma-aldrich.com.
Synonyms: 4-Allyl-1,2-methylenedioxybenzene; 5-Allyl-1,3-benzodioxole
Molecular Formula: C10H10O2
Molecular Weight: 162.19
Linear Structural Formula: C10H10O2
MDL Number: MFCD00005841
Melting Point: 11.2 C (lit.)
Density: 1.095 g/mL at 25 C (lit.)
Refractive Index: n20/D 1.537 (lit.)
Biochem Physiol Actions: Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.
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Other Notes: Principal constituent of sassafras oil